Labour leader Sir Keir Starmer is one of dozens of MPs who will see their constituency boundaries redrawn under the new electoral map proposed by the Boundary commission for England.
By law, the commission is required to draw up seats with 69,724 to 77,062 electors to make sure they are balanced in terms of voter numbers.
The proposals would see England set to gain 10 additional seats at the expense of Wales, which is due to lose eight, and Scotland, which will be down two.
In all, fewer than 10% of the 533 existing English constituencies would remain unchanged. However two that would escape with little alteration would be the prime minister’s Uxbridge and South Ruislip constituency, which would have one ward added, and the chancellor’s Richmond seat in north Yorkshire which would lose two wards.
In contrast Sir Keir’s Holborn and St Pancras constituency in north London would alter substantially, including being renamed Kentish Town and Bloomsbury.
The commission said the current electorate there is 5% above the limit, and proposed transferring three existing wards to the planned seat of Camden Town and St John’s Wood, while taking in an “orphan” ward from the neighbouring borough Islington.
The commission nevertheless said the seat would still cover the same north-south geographical range as Holborn and St Pancras, retaining nine of its existing wards.
It stressed that the proposals for England, which open for an initial eight-week public consultation period, were provisional.
It is not due to make its final recommendations to parliament until July 2023.
Commission secretary Tim Bowden said: “Today’s proposals mark the first time people get to see what the new map of parliamentary constituencies might look like. But they are just the commission’s initial thoughts.
“We want to hear the views of the public to ensure that we get the new boundaries for Parliamentary constituencies right.”
The Boundary Commissions for Scotland and Wales will publish their proposals separately.